MAF-P3 10ml IMMUNE SOLUTION
MAF-P3 has immune-modulating, detoxifying, hepatoprotective effect; inactivates free radical and peroxide compounds. The action of MAF-P3 is based on the normalization of the immune and oxidation-antioxidant systems of the body.
MAF-P3 has many phases of action which starts in minutes after first administration and has other main phases of action that last up to 4 months as stated below:
PHASE 1. In this phase two components MAF-P3 binds to a receptor that naturally binds a sugar molecule, for example, a lectin receptor. This initiates a pathway that promotes proliferation, maturation and activation of dendritic cells and other immune cells.
PHASE 2. This phase has a rapid onset which starts with macrophage activation within minutes. Effects the immune system by activation of cells of the monocyte/macrophage lineage and/or other lymphoid cells. Starting a broad expansion of immune cell populations. Activation of the CLEC10A-mediated immune response
PHASE 3. This phase starts in 2-3 hours and lasts up to 2-3 days, the detoxifying and antioxidant, restore the balance of the redox system; defence of the body is enhanced by stimulating the production of ceruloplasmin, lactoferrin, catalase activity. Normalizes lipid peroxidation, inhibits the disintegration of cell membrane phospholipids, and the synthesis of arachidonic acid, followed by a decrease in blood cholesterol and the production of inflammatory mediators. With toxic and infectious liver damage, prevents cytolysis, reduces the activity of transaminases and the level of bilirubin in the blood serum.
PHASE 4. This phase starts within 4 hours, This CLEC10A receptor activation provides the stimulus needed to actuate this activity and overcome the immunosuppressive behaviour of tumors. Suppresses the population of regulatory T cells within the tumor and the tumor microenvironment and alters the cytokine profile of the subject to enhance to efficacy of effector T cell function, by inducing a several-fold increase of IL-2, IL-12p70, IL-21, IL-27, TNFa, and IFNy in serum. Increase in serum levels of these cytokines within 4 hours.
PHASE 5. In this phase the interaction between T cells and dendritic cells leads to the formation of immunological synapse and is maintained by highly expressive adhesion modules.
PHASE 6. In this phase the dendritic cell presents an antigen to the T cells, which leads to activation and proliferation of an antigen specific population of T cells. After activation, one type of T cell CD8 kills cancer cells directly, while other T cells activate B cells to make antibodies.
PHASE 7. This phase starts at 2-3 days, lasting - up to 7-10 days, there is an intensification of the reactions of phagocytosis and death of intracellular bacteria and viruses. As a result of the activation of phagocytosis, slight exacerbation of foci of chronic inflammation, supported by the persistence of viral or bacterial agents, is possible.
PHASE 8. This phase starts on 7-10 days and lasts up to 4 months, immunomodulating effect manifests itself: restoration of disturbed parameters of cellular and humoral immunity, increase in the production of specific antibodies. The influence on the production of specific antiviral and antibacterial antibodies is equivalent to the action of certain therapeutic vaccines. Unlike the latter, MAF-P3 has no significant effect on the production of reactive antibodies of class E (IgE) and does not enhance the immediate-type hypersensitivity reaction. Stimulates the formation of IgA in its congenital insufficiency.
PHASE 9. Helps to overcome the multiple drug resistance of tumor cells mediated by the proteins of the transmembrane transport pump of the cell. Increases the sensitivity of tumor cells to the action of chemotherapeutic drugs.
1ml to 2ml every second day for 20 days Further with the repetition of courses during the entire period of subsequent treatment with a break of 15-20 days.
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